{"id":116168,"date":"2023-10-14T09:00:00","date_gmt":"2023-10-14T02:00:00","guid":{"rendered":"https:\/\/www.docosan.com\/blog\/?p=116168"},"modified":"2024-08-22T16:47:33","modified_gmt":"2024-08-22T09:47:33","slug":"thuoc-acyclovir","status":"publish","type":"post","link":"https:\/\/www.docosan.com\/blog\/thuoc-va-thuc-pham-chuc-nang\/thuoc-acyclovir\/","title":{"rendered":"Thu\u1ed1c Acyclovir c\u00f3 t\u00e1c d\u1ee5ng g\u00ec? 3 d\u1ea1ng d\u00f9ng th\u00f4ng d\u1ee5ng"},"content":{"rendered":"\r\n

Hi\u1ec7n nay, \u0111\u1ea1i \u0111a s\u1ed1 c\u00e1c c\u01a1 s\u1edf th\u0103m kh\u00e1m ch\u1eefa b\u1ec7nh, b\u1ec7nh vi\u1ec7n v\u00e0 c\u00e1c chu\u1ed7i b\u00e1n l\u1ebb thu\u1ed1c uy t\u00edn xem thu\u1ed1c kh\u00e1ng virus Acyclovir nh\u01b0 l\u00e0 l\u1ef1a ch\u1ecdn \u0111\u1ea7u tay \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb m\u1ed9t s\u1ed1 b\u1ec7nh l\u00fd do virus g\u00e2y ra tr\u00ean c\u01a1 th\u1ec3. V\u1eady, t\u1ea1i sao thu\u1ed1c Acyclovir lu\u00f4n l\u00e0 s\u1ef1 \u01b0u ti\u00ean h\u00e0ng \u0111\u1ea7u trong \u0111i\u1ec1u tr\u1ecb v\u00e0 c\u1ea7n l\u01b0u \u00fd nh\u1eefng g\u00ec tr\u01b0\u1edbc khi s\u1eed d\u1ee5ng thu\u1ed1c? H\u00e3y c\u00f9ng Doctor c\u00f3 s\u1eb5n<\/a> t\u00ecm hi\u1ec3u qua b\u00e0i vi\u1ebft n\u00e0y.<\/strong><\/p>\r\n\r\n\r\n\r\n

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\"thu\u1ed1c<\/figure>\r\n<\/figure>\r\n\r\n\r\n\r\n

V\u00e0i n\u00e9t v\u1ec1 thu\u1ed1c Acyclovir<\/h2>\r\n\r\n\r\n\r\n

Thu\u1ed1c kh\u00e1ng virus hay thu\u1ed1c ch\u1ed1ng virus l\u00e0 m\u1ed9t ph\u00e2n nh\u00f3m thu\u1ed1c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh do virus g\u00e2y n\u00ean nhi\u1ec1u h\u01a1n l\u00e0 c\u00e1c vi khu\u1ea9n, k\u00ed sinh tr\u00f9ng hay c\u00e1c lo\u1ea1i n\u1ea5m g\u00e2y b\u1ec7nh\u00a0 kh\u00e1c. Trong s\u1ed1 nh\u1eefng lo\u1ea1i thu\u1ed1c kh\u00e1ng virus, thu\u1ed1c Acyclovir l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c ph\u1ed5 bi\u1ebfn, s\u1eed d\u1ee5ng nhi\u1ec1u hi\u1ec7n nay c\u00f3 t\u00e1c kh\u00e1ng virus herpes<\/a>.<\/p>\r\n\r\n\r\n\r\n

L\u1ecbch s\u1eed ph\u00e1t tri\u1ec3n thu\u1ed1c Acyclovir<\/h3>\r\n\r\n\r\n\r\n

Theo l\u1ecbch s\u1eed ph\u00e1t tri\u1ec3n thu\u1ed1c Acyclovir, thu\u1ed1c \u0111\u01b0\u1ee3c b\u1eaft \u0111\u1ea7u nghi\u00ean c\u1ee9u t\u1eeb nh\u1eefng th\u1eadp ni\u00ean cu\u1ed1i th\u1ebf k\u1ef7 XX, nhi\u1ec1u thu\u1ed1c c\u00f3 t\u00e1c d\u1ee5ng kh\u00e1ng virus herpes to\u00e0n th\u00e2n \u0111\u00e3 ra \u0111\u1eddi, \u0111\u00e1nh d\u1ea5u b\u1edfi s\u1ef1 xu\u1ea5t hi\u1ec7n c\u1ee7a vidarabin n\u0103m 1977. Nh\u01b0ng do c\u00f3 nhi\u1ec1u \u0111\u1ed9c t\u00ednh, vidarabin ch\u1ec9 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng cho b\u1ec7nh nh\u00e2n m\u1eafc HSV hay virus Varicella zoster (VZV) v\u1edbi t\u00ecnh tr\u1ea1ng nghi\u00eam tr\u1ecdng, \u0111e d\u1ecda \u0111\u1ebfn t\u00ednh m\u1ea1ng.<\/p>\r\n\r\n\r\n\r\n

N\u0103m 1982, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 t\u00ecm ra thu\u1ed1c v\u00e0 ph\u00e1t tri\u1ec3n lo\u1ea1i thu\u1ed1c n\u00e0y \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb vi\u00eam n\u00e3o<\/a> do HSV hay zona<\/a> \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n suy gi\u1ea3m mi\u1ec5n d\u1ecbch. \u1ede n\u01b0\u1edbc ta, thu\u1ed1c \u0111\u00e3 c\u00f3 m\u1eb7t trong danh m\u1ee5c thu\u1ed1c thi\u1ebft y\u1ebfu c\u1ee7a Vi\u1ec7t Nam ban h\u00e0nh l\u1ea7n 4 n\u0103m 1999.\u00a0<\/p>\r\n\r\n\r\n\r\n

Tr\u01b0\u1edbc \u0111\u00f3, thu\u1ed1c Acyclovir \u0111\u00e3 \u0111\u01b0\u1ee3c n\u1eb1m trong danh s\u00e1ch c\u00e1c thu\u1ed1c thi\u1ebft y\u1ebfu c\u1ee7a T\u1ed5 ch\u1ee9c Y t\u1ebf Th\u1ebf gi\u1edbi, t\u1ee9c l\u00e0 nh\u00f3m c\u00e1c lo\u1ea1i thu\u1ed1c an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 nh\u1ea5t c\u1ea7n thi\u1ebft trong m\u1ed9t h\u1ec7 th\u1ed1ng y t\u1ebf. N\u00f3 c\u00f3 s\u1eb5n nh\u01b0 l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c g\u1ed1c v\u00e0 \u0111\u01b0\u1ee3c b\u00e1n tr\u00ean th\u1ecb tr\u01b0\u1eddng\u00a0 d\u01b0\u1edbi nhi\u1ec1u th\u01b0\u01a1ng hi\u1ec7u tr\u00ean to\u00e0n th\u1ebf gi\u1edbi.<\/p>\r\n\r\n\r\n\r\n

T\u00ednh ch\u1ea5t h\u00f3a l\u00fd<\/h3>\r\n\r\n\r\n\r\n

Thu\u1ed1c Acyclovir c\u00f3 c\u00f4ng th\u1ee9c ph\u00e2n t\u1eed l\u00e0 C8H11N5O3, danh ph\u00e1p h\u00f3a h\u1ecdc l\u00e0 2-amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-on l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t h\u00f3a h\u1ecdc c\u00f3 c\u1ea5u tr\u00fac t\u01b0\u01a1ng t\u1ef1 purin nucleoside l\u00e0 acycloguanin, ch\u1ec9 kh\u00e1c l\u00e0 tr\u00ean m\u1ea1ch nh\u00e1nh kh\u00f4ng c\u00f3 nh\u00f3m 3\u2019-hydroxyl.<\/p>\r\n\r\n\r\n\r\n

Th\u00f4ng th\u01b0\u1eddng, thu\u1ed1c Acyclovir l\u00e0 b\u1ed9t k\u1ebft tinh m\u00e0u tr\u1eafng ho\u1eb7c g\u1ea7n tr\u1eafng, kh\u00f3 tan trong n\u01b0\u1edbc, c\u1ed3n 96%. d\u1ec5 tan trong dung m\u00f4i dimethyl sulfoxide. Ngo\u00e0i ra, thu\u1ed1c n\u00e0y c\u00f3 tan trong c\u00e1c dung d\u1ecbch acid v\u00f4 c\u01a1 lo\u00e3ng v\u00e0 hydroxyd ki\u1ec1m lo\u00e3ng, \u0111i\u1ec3m n\u00f3ng ch\u1ea3y t\u1edbi 256,5 \u0111\u1ed9 C (t\u01b0\u01a1ng \u0111\u01b0\u01a1ng 493,7 \u0111\u1ed9 F).<\/p>\r\n\r\n\r\n\r\n

T\u01af V\u1ea4N THU\u1ed0C ACYCLOVIR<\/a><\/div>\r\n\r\n\r\n\r\n
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\"thu\u1ed1c\r\n
C\u00f4ng th\u1ee9c ph\u00e2n t\u1eed thu\u1ed1c Acyclovir<\/figcaption>\r\n<\/figure>\r\n<\/figure>\r\n\r\n\r\n\r\n

C\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng<\/h3>\r\n\r\n\r\n\r\n

Theo c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Acyclovir<\/a>, thu\u1ed1c c\u00f3 c\u1ea5u tr\u00fac h\u00f3a h\u1ecdc t\u01b0\u01a1ng t\u1ef1 acycloguanosin – m\u1ed9t lo\u1ea1i nucleotide, c\u00f3 t\u00e1c d\u1ee5ng ch\u1ecdn l\u1ecdc tr\u00ean t\u1ebf b\u00e0o nhi\u1ec5m virus herpes.\u00a0<\/p>\r\n\r\n\r\n\r\n

\u0110\u1ec3 c\u00f3 t\u00e1c d\u1ee5ng, Acyclovir ph\u1ea3i \u0111\u01b0\u1ee3c phosphoryl h\u00f3a th\u00e0nh d\u1ea1ng c\u00f3 ho\u1ea1t t\u00ednh l\u00e0 Acyclovir triphosphat. Ch\u1eb7ng \u0111\u1ea7u, Acyclovir chuy\u1ec3n th\u00e0nh Acyclovir monophosphate nh\u1edd enzym thymidine kinase c\u1ee7a virus, sau \u0111\u00f3 chuy\u1ec3n ti\u1ebfp th\u00e0nh Acyclovir diphosphat v\u00e0 triphosphat.\u00a0<\/p>\r\n\r\n\r\n\r\n

Ch\u00ednh Acyclovir triphosphat s\u1ebd \u1ee9c ch\u1ebf t\u1ed5ng h\u1ee3p DNA c\u1ee7a virus, \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 sinh s\u00f4i c\u1ee7a virus m\u00e0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng g\u00ec \u0111\u1ebfn chuy\u1ec3n h\u00f3a c\u1ee7a c\u00e1c t\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng. T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c m\u1ea1nh nh\u1ea5t tr\u00ean d\u00f2ng virus herpes simplex type 2 (HSV-2), virus Varicella zoster (VZV), t\u00e1c d\u1ee5ng y\u1ebfu nh\u1ea5t tr\u00ean cytomegalovirus (CMV), ch\u01b0a r\u00f5 t\u00e1c d\u1ee5ng tr\u00ean Epstein Barr virus.<\/p>\r\n\r\n\r\n\r\n

\u0110\u00e3 c\u00f3 nhi\u1ec1u nghi\u00ean c\u1ee9u cho th\u1ea5y virus herpes simplex \u0111\u1ec1 kh\u00e1ng thu\u1ed1c Acyclovir do xu\u1ea5t hi\u1ec7n c\u00e1c ch\u1ee7ng virus herpes simplex \u0111\u1ed9t bi\u1ebfn thi\u1ebfu h\u1ee5t hay thay \u0111\u1ed5i \u0111\u1eb7c t\u00ednh c\u1ee7a enzyme thymidine kinase c\u1ee7a virus. \u0110i\u1ec1u n\u00e0y c\u00f3 th\u1ec3 do s\u1ef1 \u0111\u1ec1 kh\u00e1ng ch\u00e9o c\u00e1c thu\u1ed1c kh\u00e1ng virus c\u00f9ng c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng nh\u01b0 ganciclovir, brivudin,…<\/p>\r\n\r\n\r\n\r\n

T\u00ecnh tr\u1ea1ng \u0111\u1ec1 kh\u00e1ng thu\u1ed1c kh\u00f4ng ch\u1ec9 di\u1ec5n ra tr\u00ean nh\u00f3m thu\u1ed1c kh\u00e1ng sinh kh\u00e1ng khu\u1ea9n m\u00e0 c\u00f2n \u0111ang di\u1ec5n ti\u1ebfn \u1edf nh\u00f3m thu\u1ed1c kh\u00e1ng virus. \u0110\u00e2y th\u1ef1c s\u1ef1 l\u00e0 v\u1ea5n \u0111\u1ec1 l\u1edbn cho ng\u01b0\u1eddi b\u1ecb suy gi\u1ea3m mi\u1ec5n d\u1ecbch, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u0111\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh AIDS<\/a> hay nhi\u1ec5m virus herpes simplex kh\u00e1ng thu\u1ed1c Acyclovir \u1edf tr\u00ean da hay ni\u00eam m\u1ea1c.<\/p>\r\n\r\n\r\n\r\n

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\"Thu\u1ed1c\r\n
Thu\u1ed1c Acyclovir cho t\u00e1c d\u1ee5ng m\u1ea1nh tr\u00ean virus herpes simplex<\/figcaption>\r\n<\/figure>\r\n<\/figure>\r\n\r\n\r\n\r\n

Ch\u1ec9 \u0111\u1ecbnh<\/h3>\r\n\r\n\r\n\r\n