{"id":116200,"date":"2023-10-17T13:00:00","date_gmt":"2023-10-17T06:00:00","guid":{"rendered":"https:\/\/www.docosan.com\/blog\/?p=116200"},"modified":"2024-08-06T15:50:34","modified_gmt":"2024-08-06T08:50:34","slug":"thuoc-halixol","status":"publish","type":"post","link":"https:\/\/www.docosan.com\/blog\/thuoc-va-thuc-pham-chuc-nang\/thuoc-halixol\/","title":{"rendered":"Thu\u1ed1c Halixol d\u00f9ng nh\u01b0 th\u1ebf n\u00e0o? Gi\u00e1 bao nhi\u00eau n\u0103m 2024?"},"content":{"rendered":"\r\n

Halixol l\u00e0 m\u1ed9t trong c\u00e1c thu\u1ed1c ho \u0111\u01b0\u1ee3c \u01b0u ti\u00ean l\u1ef1a ch\u1ecdn gi\u00fap l\u00e0m ti\u00eau gi\u1ea3m ch\u1ea5t nh\u1ea7y v\u00e0 \u0111\u1eddm, gi\u00fap l\u00e0m gi\u1ea3m c\u00e1c tri\u1ec7u ch\u1ee9ng tr\u00ean \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p. H\u00e3y c\u00f9ng Doctor c\u00f3 s\u1eb5n t\u00ecm hi\u1ec3u chi ti\u1ebft v\u1ec1 th\u00f4ng tin thu\u1ed1c ho Halixol c\u0169ng nh\u01b0 t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c tr\u00ean t\u1eebng \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n nh\u00e9.\u00a0<\/strong><\/p>\r\n\r\n\r\n\r\n

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\"thu\u1ed1c<\/figure>\r\n<\/figure>\r\n\r\n\r\n\r\n

Thu\u1ed1c Halixol l\u00e0 thu\u1ed1c g\u00ec?<\/h2>\r\n\r\n\r\n\r\n

Ambroxol<\/a> (2-amino-3,5-dibromo-N-[trans-4-hydroxycyclohexyl]benzylamine) l\u00e0 m\u1ed9t thu\u1ed1c thu\u1ed9c nh\u00f3m c\u00e1c thu\u1ed1c c\u1ea7n k\u00ea \u0111\u01a1n, c\u00f3 ho\u1ea1t t\u00ednh ti\u00eau nh\u1ea7y v\u00e0 \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng r\u1ed9ng r\u00e3i \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u1ea3 b\u1ec7nh h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh v\u00e0 m\u00e3n t\u00ednh k\u1ec3 t\u1eeb n\u0103m 1978.\u00a0<\/p>\r\n\r\n\r\n\r\n

T\u01b0\u01a1ng t\u1ef1 nh\u01b0 h\u1ee3p ch\u1ea5t g\u1ed1c bromhexin, ambroxol c\u00f3 c\u1ea3 t\u00e1c d\u1ee5ng l\u00ean ni\u00eam m\u1ea1c v\u00e0 ni\u00eam m\u1ea1c nh\u01b0 \u0111\u00e3 th\u1ea5y trong c\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng v\u1edbi b\u1ec7nh nh\u00e2n tr\u01b0\u1edfng th\u00e0nh m\u1eafc b\u1ec7nh h\u00f4 h\u1ea5p.\u00a0<\/p>\r\n\r\n\r\n\r\n

H\u01a1n n\u1eefa, s\u1ef1 kh\u00e1c bi\u1ec7t v\u1ec1 c\u1ea5u tr\u00fac v\u1edbi bromhexin, ch\u1eb3ng h\u1ea1n nh\u01b0 s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a nh\u00f3m hydroxyl \u1edf v\u1ecb tr\u00ed para-trans c\u1ee7a v\u00f2ng cyclohexyl v\u00e0 vi\u1ec7c lo\u1ea1i b\u1ecf nh\u00f3m methyl, \u0111\u00e3 mang l\u1ea1i cho ambroxol c\u00e1c \u0111\u1eb7c t\u00ednh d\u01b0\u1ee3c l\u00fd b\u1ed5 sung, bao g\u1ed3m k\u00edch th\u00edch s\u1ea3n xu\u1ea5t ch\u1ea5t ho\u1ea1t \u0111\u1ed9ng b\u1ec1 m\u1eb7t, kh\u00e1ng vi\u00eam, t\u00e1c d\u1ee5ng ch\u1ed1ng oxy h\u00f3a v\u00e0 t\u00e1c d\u1ee5ng g\u00e2y t\u00ea c\u1ee5c b\u1ed9.<\/p>\r\n\r\n\r\n\r\n

Thu\u1ed1c ho Halixol<\/strong> v\u1edbi m\u1ed9t s\u1ed1 \u0111\u1eb7c t\u00ednh bao g\u1ed3m c\u00e1c ho\u1ea1t \u0111\u1ed9ng ti\u1ebft v\u00e0 v\u1eadn \u0111\u1ed9ng b\u00e0i ti\u1ebft gi\u00fap kh\u00f4i ph\u1ee5c c\u01a1 ch\u1ebf thanh th\u1ea3i sinh l\u00fd c\u1ee7a \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p. N\u00f3 k\u00edch th\u00edch s\u1ef1 t\u1ed5ng h\u1ee3p v\u00e0 gi\u1ea3i ph\u00f3ng ch\u1ea5t ho\u1ea1t \u0111\u1ed9ng b\u1ec1 m\u1eb7t c\u1ee7a t\u1ebf b\u00e0o ph\u1ed5i lo\u1ea1i II. Ch\u1ea5t ho\u1ea1t \u0111\u1ed9ng b\u1ec1 m\u1eb7t ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t y\u1ebfu t\u1ed1 ch\u1ed1ng keo b\u1eb1ng c\u00e1ch l\u00e0m gi\u1ea3m s\u1ef1 b\u00e1m d\u00ednh c\u1ee7a ch\u1ea5t nh\u1ea7y v\u00e0o th\u00e0nh ph\u1ebf qu\u1ea3n, c\u1ea3i thi\u1ec7n s\u1ef1 v\u1eadn chuy\u1ec3n c\u1ee7a n\u00f3 v\u00e0 cung c\u1ea5p s\u1ef1 b\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i nhi\u1ec5m tr\u00f9ng v\u00e0 c\u00e1c t\u00e1c nh\u00e2n g\u00e2y k\u00edch \u1ee9ng.<\/p>\r\n\r\n\r\n\r\n

Ambroxol c\u00f3 s\u1eb5n \u1edf nhi\u1ec1u d\u1ea1ng c\u00f4ng th\u1ee9c, bao g\u1ed3m vi\u00ean ng\u1eadm, dung d\u1ecbch ti\u00eam b\u1eafp v\u00e0 ti\u00eam t\u0129nh m\u1ea1ch, siro, h\u1ea1t, vi\u00ean n\u00e9n, d\u1ea1ng u\u1ed1ng gi\u1ea3i ph\u00f3ng ch\u1eadm v\u00e0 dung d\u1ecbch kh\u00ed dung. \u0110\u1ec3 \u0111i\u1ec1u tr\u1ecb tr\u1ebb em m\u1eafc c\u00e1c b\u1ec7nh h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh v\u00e0 m\u00e3n t\u00ednh li\u00ean quan \u0111\u1ebfn s\u1ef1 ti\u1ebft ch\u1ea5t nh\u1ea7y b\u1ea5t th\u01b0\u1eddng v\u00e0 kh\u1ea3 n\u0103ng v\u1eadn chuy\u1ec3n ch\u1ea5t nh\u1ea7y b\u1ecb suy gi\u1ea3m, Ambroxol c\u00f3 s\u1eb5n d\u01b0\u1edbi d\u1ea1ng siro kh\u00f4ng k\u00ea \u0111\u01a1n. C\u00e1c ch\u1ec9 \u0111\u1ecbnh \u0111\u01b0\u1ee3c c\u1ea5p ph\u00e9p kh\u00e1c c\u1ee7a Ambroxol bao g\u1ed3m d\u1ef1 ph\u00f2ng v\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c bi\u1ebfn ch\u1ee9ng ph\u1ebf qu\u1ea3n ph\u1ed5i sau ph\u1eabu thu\u1eadt, gi\u1ea3m \u0111au trong vi\u00eam h\u1ecdng c\u1ea5p t\u00ednh<\/a> (ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u1ebb em tr\u00ean 12 tu\u1ed5i).<\/p>\r\n\r\n\r\n\r\n

Hi\u1ec7n t\u1ea1i tr\u00ean th\u1ecb tr\u01b0\u1eddng Vi\u1ec7t Nam c\u00f3 2 d\u1ea1ng thu\u1ed1c Ambroxol th\u01b0\u1eddng d\u00f9ng l\u00e0 d\u1ea1ng vi\u00ean n\u00e9n v\u00e0 d\u1ea1ng siro \u0111\u01b0\u1ee3c l\u01b0u h\u00e0nh v\u1edbi t\u00ean bi\u1ec7t d\u01b0\u1ee3c l\u00e0 Halixol thu\u1ed9c s\u1ea3n ph\u1ea9m c\u1ee7a c\u00f4ng ty Egis Pharmaceutical Public Limited c\u00f3 tr\u1ee5 s\u1edf t\u1ea1i Hungary.\u00a0<\/p>\r\n\r\n\r\n\r\n

T\u01af V\u1ea4N THU\u1ed0C HALIXOL<\/a><\/div>\r\n\r\n\r\n\r\n
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\"Ambroxol\r\n
Ambroxol l\u00e0 ho\u1ea1t ch\u1ea5t c\u1ee7a Halixol thu\u1ed9c nh\u00f3m long \u0111\u1eddm, ti\u00eau h\u1ee7y ch\u1ea5t nh\u1ea7y<\/figcaption>\r\n<\/figure>\r\n<\/figure>\r\n\r\n\r\n\r\n

Ambroxol gi\u00fap l\u00e0m t\u0103ng sinh c\u00e1c lysosome v\u00e0 t\u0103ng c\u01b0\u1eddng t\u00e1c d\u1ee5ng c\u1ee7a c\u00e1c enzyme th\u1ee7y ph\u00e2n \u1edf c\u00e1c t\u1ebf b\u00e0o ti\u1ebft ch\u1ea5t nh\u1ea7y, th\u00fac \u0111\u1ea9y ph\u00e2n gi\u1ea3i d\u1ecbch ti\u1ebft ph\u1ebf qu\u1ea3n v\u00e0 c\u1eaft c\u00e1c s\u1ee3i acid mucopolysaccharides. \u0110\u1ed3ng th\u1eddi, c\u00e1c tuy\u1ebfn thanh d\u1ecbch \u0111\u01b0\u1ee3c k\u00edch th\u00edch l\u00e0m cho d\u1ecbch ti\u1ebft \u00edt \u0111\u1eb7c h\u01a1n. Trong c\u00e1c b\u1ec7nh l\u00fd vi\u00eam \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p, Ambroxol k\u00edch th\u00edch s\u1ea3n sinh c\u00e1c ch\u1ea5t c\u00f3 ho\u1ea1t t\u00ednh b\u1ec1 m\u1eb7t v\u00e0 c\u00f3 t\u00e1c d\u1ee5ng t\u0103ng c\u01b0\u1eddng l\u00e0m s\u1ea1ch c\u00e1c mao nh\u1ea7y.<\/p>\r\n\r\n\r\n\r\n

Ambroxol g\u1ea7n nh\u01b0 \u0111\u01b0\u1ee3c h\u1ea5p thu ho\u00e0n to\u00e0n qua \u0111\u01b0\u1eddng ti\u00eau h\u00f3a. Sau \u0111\u00f3, thu\u1ed1c Ambroxol \u0111\u01b0\u1ee3c chuy\u1ec3n h\u00f3a m\u1ea1nh qua qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a\u00a0 l\u1ea7n \u0111\u1ea7u t\u1ea1i gan. Sinh kh\u1ea3 d\u1ee5ng c\u1ee7a ambroxol \u0111\u01b0\u1eddng u\u1ed1ng kho\u1ea3ng 60%, c\u00f3 kho\u1ea3ng 80% l\u01b0\u1ee3ng thu\u1ed1c trong m\u00e1u \u0111\u01b0\u1ee3c g\u1eafn k\u1ebft v\u1edbi protein huy\u1ebft t\u01b0\u01a1ng.<\/p>\r\n\r\n\r\n\r\n

Ngo\u00e0i ram c\u00f3 kho\u1ea3ng 80% li\u1ec1u d\u00f9ng Ambroxol \u0111\u01b0\u1ee3c \u0111\u00e0o th\u1ea3i qua n\u01b0\u1edbc ti\u1ec3u d\u01b0\u1edbi d\u1ea1ng ch\u01b0a bi\u1ebfn \u0111\u1ed5i v\u00e0 d\u01b0\u1edbi d\u1ea1ng li\u00ean h\u1ee3p glucuronide c\u1ee7a c\u00e1c ch\u1ea5t chuy\u1ec3n h\u00f3a oxy h\u00f3a. Qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a c\u1ee7a Ambroxol tr\u1ea3i qua 2 pha v\u00e0 th\u1eddi gian b\u00e1n th\u1ea3i bi\u1ec3u ki\u1ebfn c\u1ee7a 2 pha t\u01b0\u01a1ng \u1ee9ng l\u00e0 1,3 gi\u1edd v\u00e0 8,8 gi\u1edd.<\/p>\r\n\r\n\r\n\r\n

\u0110\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng<\/a>: Th\u1eddi gian b\u00e1n th\u1ea3i c\u1ee7a Ambroxol t\u0103ng l\u00ean \u1edf b\u1ec7nh nh\u00e2n suy th\u1eadn n\u1eb7ng do \u0111\u00f3 b\u00e1c s\u0129 c\u1ea7n ph\u1ea3i gi\u1ea3m li\u1ec1u ho\u1eb7c t\u0103ng kho\u1ea3ng c\u00e1ch gi\u1eefa c\u00e1c l\u1ea7n d\u00f9ng thu\u1ed1c \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n n\u00e0y.\u00a0<\/p>\r\n\r\n\r\n\r\n

Ambroxol trong nhi\u1ec1u nghi\u00ean c\u1ee9u cho th\u1ea5y n\u00f3 qua \u0111\u01b0\u1ee3c h\u00e0ng r\u00e0o nhau thai v\u00e0 n\u1ed3ng \u0111\u1ed9 c\u1ee7a thu\u1ed1c trong huy\u1ebft thanh thai nhi cao g\u1ea5p 2-4 l\u1ea7n n\u1ed3ng \u0111\u1ed9 thu\u1ed1c trong c\u01a1 th\u1ec3 m\u1eb9 v\u00e0 Ambroxol c\u0169ng \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong s\u1eefa m\u1eb9 v\u00e0 d\u1ecbch n\u00e3o t\u1ee7y.<\/p>\r\n\r\n\r\n\r\n

T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Halixol<\/h2>\r\n\r\n\r\n\r\n

Thu\u1ed1c Halixol vi\u00ean n\u00e9n 30mg<\/h3>\r\n\r\n\r\n\r\n

M\u1ed7i vi\u00ean n\u00e9n Halixol c\u00f3 ch\u1ee9a 30mg Ambroxol hydrochloride v\u00e0 c\u00e1c t\u00e1 d\u01b0\u1ee3c lactose monohydrate,microcrystalline cellulose, povidone K30, sodium starch glycolate magnesium stearat.\u00a0<\/p>\r\n\r\n\r\n\r\n

M\u00f4 t\u1ea3 vi\u00ean n\u00e9n: Vi\u00ean n\u00e9n m\u00e0u tr\u1eafng h\u00ecnh tr\u00f2n, kh\u00f4ng m\u00f9i, m\u1ed9t m\u1eb7t c\u00f3 g\u1ea1ch ngang, m\u1eb7t c\u00f2n l\u1ea1i c\u00f3 ch\u1eef s\u1ed1 E231.<\/p>\r\n\r\n\r\n\r\n

Ch\u1ec9 \u0111\u1ecbnh c\u1ee7a thu\u1ed1c Halixol vi\u00ean n\u00e9n: T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c Halixol l\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh v\u00e0 m\u00e3n t\u00ednh nh\u01b0 hen ph\u1ebf qu\u1ea3n<\/a> v\u00e0 vi\u00eam ph\u1ebf qu\u1ea3n<\/a>, gi\u00e3n ph\u1ebf qu\u1ea3n do s\u1ea3n sinh qu\u00e1 nhi\u1ec1u nh\u1ea7y v\u00e0 \u0111\u1eddm. Ngo\u00e0i ra, ho\u1ea1t ch\u1ea5t Ambroxol trong thu\u1ed1c c\u00f2n t\u0103ng c\u01b0\u1eddng h\u00f2a tan d\u1ecbch nh\u1ea7y trong c\u00e1c b\u1ec7nh vi\u00eam m\u0169i, h\u1ecdng.<\/p>\r\n\r\n\r\n\r\n

T\u01af V\u1ea4N THU\u1ed0C HALIXOL<\/a><\/div>\r\n\r\n\r\n\r\n
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\"Thu\u1ed1c\r\n
Thu\u1ed1c Halixol 30mg d\u1ea1ng vi\u00ean n\u00e9n\u00a0<\/figcaption>\r\n<\/figure>\r\n<\/figure>\r\n\r\n\r\n\r\n

Thu\u1ed1c Halixol siro 100ml<\/strong><\/h3>\r\n\r\n\r\n\r\n

M\u1ed7i chai siro Halixol 100mg c\u00f3 ch\u1ee9a 300mg ambroxol hydrochloride (15mg trong m\u1ed7i 5ml siro) v\u00e0 c\u00e1c t\u00e1 d\u01b0\u1ee3c Sorbitol (1,2g\/5ml siro), sodium citrate, sodium benzoate, h\u01b0\u01a1ng chu\u1ed1i, h\u01b0\u01a1ng d\u00e2u, sodium cyclamate, citric acid monohydrate, povidone, n\u01b0\u1edbc tinh khi\u1ebft.\u00a0<\/p>\r\n\r\n\r\n\r\n

M\u00f4 t\u1ea3 siro: Ch\u1ea5t l\u1ecfng trong, v\u00e0ng nh\u1ea1t, c\u00f3 m\u00f9i \u0111\u1eb7c tr\u01b0ng, ch\u1ee9a trong chai th\u1ee7y tinh n\u00e2u c\u00f3 k\u00e8m n\u1eafp chia li\u1ec1u.\u00a0<\/p>\r\n\r\n\r\n\r\n

Ch\u1ec9 \u0111\u1ecbnh c\u1ee7a siro Halixol 100ml: T\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c l\u00e0 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh t\u1eafc ngh\u1ebdn \u0111\u01b0\u1eddng h\u00f4 h\u1ea5p c\u1ea5p t\u00ednh v\u00e0 m\u00e3n t\u00ednh nh\u01b0 hen ph\u1ebf qu\u1ea3n v\u00e0 vi\u00eam ph\u1ebf qu\u1ea3n, gi\u00e3n ph\u1ebf qu\u1ea3n do s\u1ea3n sinh qu\u00e1 nhi\u1ec1u nh\u1ea7y v\u00e0 \u0111\u1eddm. Ngo\u00e0i ra, ho\u1ea1t ch\u1ea5t Ambroxol trong Halixol c\u00f2n t\u0103ng c\u01b0\u1eddng h\u00f2a tan d\u1ecbch nh\u1ea7y trong c\u00e1c b\u1ec7nh vi\u00eam m\u0169i, h\u1ecdng.<\/p>\r\n\r\n\r\n\r\n

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\"Thu\u1ed1c\r\n
Thu\u1ed1c Halixol d\u1ea1ng siro<\/figcaption>\r\n<\/figure>\r\n<\/figure>\r\n\r\n\r\n\r\n

Li\u1ec1u d\u00f9ng v\u00e0 c\u00e1ch d\u00f9ng thu\u1ed1c Halixol<\/strong><\/h3>\r\n\r\n\r\n\r\n

Thu\u1ed1c Halixol vi\u00ean n\u00e9n 30mg:\u00a0<\/strong><\/p>\r\n\r\n\r\n\r\n